Confirmation of neurometabolic diagnoses using age‐dependent cerebrospinal fluid metabolomic profiles
نویسندگان
چکیده
منابع مشابه
The human cerebrospinal fluid metabolomic database
database Cerebrospinal fluid (CSF) is considered to be an excellent source of molecular biomarkers of neurological function since it is in direct contact with the extracellular space of the brain. As the CSF contains metabolites and other molecules that can reflect altered brain function, sys tematic studies of the CSF metabolome can potentially offer new insights into central nervous system (...
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Models used for Model-Based Diagnosis usually assume that the inaccuracy of data is smaller than the precision with which the data is described. In some domains, however, this assumption is invalid. Observations may not be accurate or the behavior model of the system does not allow for accurate predictions. Therefore, the accuracy of predictions, which is a function of the accuracy of the obser...
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Purpose Early diagnosis of leptomeningeal carcinomatosis (LMC) is necessary to improve outcomes of this formidable disease. However, cerebrospinal fluid (CSF) cytology is frequently false negative. We examined whether CSF metabolome profiles can be used to differentiate patients with LMC from patients having a risk for development of LMC. Results A total of 10,905 LMIs were evaluated using PC...
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ژورنال
عنوان ژورنال: Journal of Inherited Metabolic Disease
سال: 2020
ISSN: 0141-8955,1573-2665
DOI: 10.1002/jimd.12253